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A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
Published on: December 23, 2016
Facile and unified approach to skeletally diverse, privileged scaffolds
James J Sahn1, Justin Y Su, Stephen F Martin
1Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, United States.
Abstract:
A novel strategy has been developed to generate a diverse array of privileged scaffolds from readily available tetrahydropyridine precursors that may be prepared by a multicomponent assembly process followed by a ring-closing metathesis. The functionality embedded in these key intermediates enables their facile elaboration into more complex structures of biological relevance by a variety of ring-forming processes and refunctionalizations.
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