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Endocrine parameters in acne vulgaris.

J B Schmidt¹, A Lindmaier, J Spona

¹Department of Dermatology II, University of Vienna, Austria.

Endocrinologia Experimentalis

|December 1, 1990

Summary

This study found androgens play a greater role in female acne than male acne. Elevated cortisol (F) was observed in both male and female acne patients, suggesting suprarenal involvement.

Area of Science:

Endocrinology
Dermatology
Androgen Biology

Background:

Acne vulgaris is a common skin condition with complex etiologies.
Hormonal imbalances, particularly androgens, are implicated in acne pathogenesis.
Previous research suggests differing hormonal influences in male and female acne.

Purpose of the Study:

To investigate hormonal profiles in male and female acne patients.
To compare hormone levels between acne patients and healthy controls.
To explore correlations between specific hormones and acne lesion counts.

Main Methods:

Hormonal assays (radioimmunoassay) for testosterone, DHEAS, androstenedione, free testosterone, 17-OHP, SHBG, FSH, LH, prolactin, estradiol, and cortisol.
Clinical assessment of acne lesion counts.

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Comparison of hormonal levels and lesion counts between acne patients and controls, stratified by sex.

Main Results:

Female acne patients showed elevated testosterone, dehydroepiandrosterone (DHEA), and cortisol (F), with decreased estradiol.
Male acne patients exhibited only elevated cortisol (F).
Correlations between testosterone (free and total) and acne lesions were observed in both sexes, with free testosterone and androstenedione showing stronger links in females.

Conclusions:

Androgens appear to play a more significant role in female acne compared to male acne.
Elevated cortisol in both male and female acne patients suggests suprarenal gland involvement.
Hormonal and peripheral skin factors contribute to acne development, with sex-specific differences observed.