CNS neoplasms in Pakistan, a pathological perspective.
Zubair Ahmad1, Huma Arshad, Sheema H Hasan
1Department of Pathology and Microbiology, Aga Khan University, Karachi, Pakistan. zubair.ahmad@aku.edu
Asian Pacific Journal of Cancer Prevention : APJCP
|April 27, 2011
Summary
The Aga Khan University
Area of Science:
- Neuropathology and Histopathology
- Central Nervous System (CNS) Neoplasms
- Oncology Diagnostics
Background:
- The Section of Histopathology at Aga Khan University is Pakistan's largest histopathology center.
- It serves as a primary reporting and referral hub for CNS neoplasms nationwide.
- An increasing annual caseload of CNS neoplasms has been observed.
Purpose of the Study:
- To analyze trends in CNS neoplasm reporting.
- To identify challenges faced in histopathological diagnosis of CNS neoplasms.
- To highlight the need for improved clinical data in diagnostic workflows.
Main Methods:
- Retrospective analysis of annual CNS neoplasm case reporting.
- Review of diagnostic procedures and data submission quality.
- Identification of common omissions in submitted case information.
Main Results:
- A significant annual increase in CNS neoplasm cases reported.
- The rise in cases is likely correlated with an increase in neurosurgical procedures.
- A substantial number of cases lack essential clinical history or radiological imaging.
Conclusions:
- The histopathology section is a key diagnostic center for CNS neoplasms in Pakistan.
- Increased neurosurgical activity contributes to the rising caseload.
- Incomplete clinical information presents a significant diagnostic challenge for histopathologists.
Related Concept Videos
Brain Abscess l: Introduction
A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
Cushing Syndrome II: Pathophysiology
Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...

