Related Experiment Videos
[In vitro study, in perfused rabbit heart, of interaction between two anti-arrhythmia agents: amiodarone and
H Akhdim1, J P Kantelip, B Stimmesse
1Chaire de Pharmacologie, Faculté de Médecine et de Pharmacie, Université de Franche-Comté, Besançon.
Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales
|January 1, 1990
Abstract:
The influence of 15 day's amiodarone administration (30 mg/kg/day) on myocardial uptake kinetics and electrocardiographic changes of disopyramide was examined on the isolated perfused rabbit heart (n = 24) under electrical stimulation. Amiodarone significantly reduced myocardial uptake and potentialized the effect of disopyramide on intraventricular conduction.