Related Experiment Video
Updated: Jun 2, 2026

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
Published on: July 22, 2021
Update in surgery for osteoarthritis of the knee
Peter F M Choong1, Michelle M Dowsey
1Department of Orthopaedics Surgery, University of Melbourne, St Vincent's Hospital, Melbourne, Victoria, Australia. pchoong@unimelb.edu.au
Abstract:
Osteoarthritis is a leading cause of disability with incidence and prevalence rising in most nations. Management to address the degenerative joint is stratified according to degree of severity of involvement and always begins with non-surgical modalities before progressing through a range of surgeries, including arthroscopy, osteotomy, unicompartmental and total knee replacement. Predictability of results depends on the type of procedure with total joint replacement giving the most sustainable relief from symptoms, improvement of function and longevity of construct. Obesity is a health priority in developed countries where it is overrepresented in patients presenting for joint replacement. Complications, poor patient satisfaction and joint function can be directly attributable to obesity. Efforts to address obesity should be considered as part of the approach to managing osteoarthritis.