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Updated: Jun 2, 2026

Local Anesthetic Thoracoscopy for Undiagnosed Pleural Effusion
Published on: November 10, 2023
Management of malignant pleural effusions.
Francisco Rodriguez-Panadero1, Beatriz Romero-Romero
1Unidad Médico-Quirúrgica de Enfermedades Respiratorias (UMQER) and Instituto de Biomedicina de Sevilla (HUVR-IBiS), Sevilla, Spain. frpanad@ono.com
Talc pleurodesis remains the most effective treatment for malignant pleural effusions (MPEs). Indwelling pleural catheters offer a viable alternative for select patients, improving MPE management.
Area of Science:
- Pulmonology
- Oncology
- Thoracic Surgery
Background:
- Malignant pleural effusions (MPEs) are a common clinical challenge.
- Optimal management strategies for MPEs are continuously sought.
- Current treatments for MPEs lack a definitive optimal approach.
Purpose of the Study:
- To review recent advancements in the management of malignant pleural effusions.
- To emphasize current therapeutic options including pleurodesis and indwelling pleural catheters.
- To explore potential improvements in MPE treatment.
Main Methods:
- Comprehensive review of recent literature on MPE treatment.
- Focus on pleurodesis agents and indwelling pleural catheter (IPC) placement.
- Inclusion of translational medicine advances relevant to MPEs.
Main Results:
- Talc is the most effective pleurodesis agent, with calibrated, large-particle talc recommended to minimize complications.
- Indwelling pleural catheters (IPCs) are increasingly accepted and suitable for patients with lung entrapment or failed pleurodesis.
- Iodopovidone, silver nitrate, and doxycycline are alternative pleurodesis agents.
Conclusions:
- Recent findings offer significant improvements in managing malignant pleural effusions.
- These advancements are particularly beneficial for patients with advanced disease unsuitable for pleurodesis.
- The study highlights the growing role of IPCs and refined pleurodesis techniques.
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