Related Experiment Video

Updated: Jun 2, 2026

Isolation of Single Intracellular Bacterial Communities Generated from a Murine Model of Urinary Tract Infection for Downstream Single-cell Analysis
07:34

Isolation of Single Intracellular Bacterial Communities Generated from a Murine Model of Urinary Tract Infection for Downstream Single-cell Analysis

Published on: April 16, 2019

Novel management of urinary tract infections

Douglas W Storm1, Ashay S Patel, Stephen A Koff

  • 1Department of Urology, Naval Medical Center, San Diego, California, USA.

Current Opinion in Urology
|April 27, 2011
PubMed

Insights

New approaches to pediatric urinary tract infections (UTIs) and vesicoureteral reflux are emerging. Research into host-pathogen interactions suggests probiotics may prevent kidney scarring from UTIs.

Area of Science:

  • Pediatric Nephrology
  • Infectious Diseases
  • Microbiology

Background:

  • Conventional management of pediatric urinary tract infections (UTIs) and vesicoureteral reflux (VUR) is being re-evaluated.
  • Prophylactic antibiotics are traditionally used but recent studies question their efficacy in preventing recurrent UTIs and renal scarring.

Purpose of the Study:

  • To review current observations necessitating a shift in UTI and VUR management for children.
  • To explore novel strategies for UTI prevention and renal scarring mitigation.
  • To investigate the role of host-pathogen interactions in developing alternative approaches.

Main Methods:

  • Review of recent studies on pediatric UTIs and VUR.
  • Analysis of research on bacterial virulence factors in UTIs.
  • Investigation of host-pathogen interactions and their implications for treatment.

Main Results:

  • Recent findings challenge the routine use of prophylactic antibiotics for children with VUR.
  • Host-pathogen interaction research enables analysis of bacterial virulence.
  • Identification of highly virulent bacteria and their gut reservoirs is now possible.
  • Probiotics show promise in targeting and eliminating uropathogenic bacteria.

Conclusions:

  • Experimental studies link bacterial virulence to UTI patterns.
  • A novel probiotic can eradicate uropathogenic bacteria.
  • Targeted probiotic prevention of renal injury-inducing UTIs is a potential therapeutic strategy.
Abstract

More Related Videos

Establishment and Characterization of UTI and CAUTI in a Mouse Model08:40

Establishment and Characterization of UTI and CAUTI in a Mouse Model

Published on: June 23, 2015

Urinary Tract Infection in a Small Animal Model: Transurethral Catheterization of Male and Female Mice10:23

Urinary Tract Infection in a Small Animal Model: Transurethral Catheterization of Male and Female Mice

Published on: December 1, 2017

Related Concept Videos

Urinary Tract Infection IV: Nursing Management01:17

Urinary Tract Infection IV: Nursing Management

In managing urinary tract infections (UTIs) in nursing, a comprehensive assessment is essential. Begin by gathering subjective data, such as the patient’s complaints of dysuria (painful urination), urinary frequency, urgency, suprapubic pain, and any lower abdominal discomfort. This information can be complemented by questions regarding previous UTIs, sexual activity, and personal hygiene practices, which can provide insight into risk factors. Objective assessment should focus on signs like...
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
Urinary Tract Calculi V: Nursing Management01:28

Urinary Tract Calculi V: Nursing Management

AssessmentSubjective Data: Obtain a detailed health history, including any recent or chronic urinary tract infections, periods of immobilization, previous episodes of renal calculi, and medical conditions such as gout, benign prostatic hyperplasia, or hyperparathyroidism. Review the medication history for drugs that may influence stone formation, including allopurinol, analgesics, loop diuretics, or thiazide diuretics. Document the use of long-term indwelling catheters and any past surgical...
Urinary Tract Calculi III: Medical Management01:30

Urinary Tract Calculi III: Medical Management

The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Urinary Tract Calculi VI: Surgical Management01:25

Urinary Tract Calculi VI: Surgical Management

Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...