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Related Concept Videos

Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Pharmacogenetics and Pharmacogenomics: Overview01:29

Pharmacogenetics and Pharmacogenomics: Overview

Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
Pharmacogenetics of Drug Metabolism: Overview01:27

Pharmacogenetics of Drug Metabolism: Overview

Genetic polymorphism in drug metabolism is crucial to the inter-individual variability observed in drug responses. Drug metabolism primarily involves the chemical modification of drugs and other xenobiotics to enhance their elimination by increasing their polarity. Two main classes of enzymes mediate this biotransformation process: Phase I enzymes, primarily cytochrome P450s, catalyze oxidation and reduction reactions, while other enzymes, such as esterases, mediate hydrolysis, and Phase II...
Principles of Pharmacogenetics: Types of Genetic Variants01:27

Principles of Pharmacogenetics: Types of Genetic Variants

The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...

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Updated: Jun 2, 2026

A Computerized Functional Skills Assessment and Training Program Targeting Technology Based Everyday Functional Skills
07:31

A Computerized Functional Skills Assessment and Training Program Targeting Technology Based Everyday Functional Skills

Published on: February 13, 2020

Pharmacogenomics training using an instructional software system.

John A Springer1, Nicholas V Iannotti, Michael D Kane

  • 1Department of Computer and Information Technology, Purdue University.

American Journal of Pharmaceutical Education
|April 27, 2011
PubMed
Summary
This summary is machine-generated.

An elective pharmacogenomics course equipped pharmacy students with essential knowledge for personalized medicine. Students demonstrated increased confidence in using genomic data for drug dosing and genetic profiling.

Keywords:
drug safetyinstructional softwarepersonalized medicinepharmacogenomics

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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Area of Science:

  • Pharmacogenomics education
  • Genomic biotechnology integration
  • Pharmacy practice evolution

Background:

  • Pharmacogenomics is transforming healthcare, necessitating specialized pharmacy training.
  • The integration of genomic data into clinical practice requires new pharmacist competencies.

Purpose of the Study:

  • To implement and evaluate an elective pharmacogenomics course for pharmacy students.
  • To prepare students for the impact of pharmacogenomics on the pharmacy profession.

Main Methods:

  • An 8-session course covering pharmacogenomics basics, genomic biotechnology, and ethical considerations.
  • Utilized GeneScription software for a simulated professional pharmacy environment.
  • Assessed student learning through patient education pamphlets, papers, and pre/post-course surveys.

Main Results:

  • Post-course surveys indicated strong student agreement on using genomic data for optimal drug dosing.
  • Students showed increased willingness to submit DNA data for genetic profiling.
  • Enhanced understanding of DNA analysis and secure genomic data storage was observed.

Conclusions:

  • The elective course provided foundational knowledge for clinical pharmacogenomic decision-making.
  • Students gained skills to educate healthcare professionals and patients about pharmacogenomics.
  • Pharmacists and students require pharmacogenomics education for the advancement of personalized medicine.