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Related Experiment Video

Updated: Jun 2, 2026

Investigating the Protective Effects of Platycodin D on Non-Alcoholic Fatty Liver Disease in a Palmitic Acid-Induced In Vitro Model

Investigating the Protective Effects of Platycodin D on Non-Alcoholic Fatty Liver Disease in a Palmitic Acid-Induced In Vitro Model

Published on: December 2, 2022

Association between thyroid function and nonalcoholic fatty liver disease in euthyroid elderly Chinese.

Chengfu Xu¹, Lei Xu, Chaohui Yu

¹Department of Gastroenterology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Clinical Endocrinology

|April 28, 2011

Summary

Thyroid function within the normal range is linked to nonalcoholic fatty liver disease (NAFLD) in elderly Chinese. Lower free thyroxine (FT4) levels correlate with a higher risk of NAFLD.

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Last Updated: Jun 2, 2026

Investigating the Protective Effects of Platycodin D on Non-Alcoholic Fatty Liver Disease in a Palmitic Acid-Induced In Vitro Model

Investigating the Protective Effects of Platycodin D on Non-Alcoholic Fatty Liver Disease in a Palmitic Acid-Induced In Vitro Model

Published on: December 2, 2022

Area of Science:

Endocrinology
Hepatology
Geriatrics

Background:

Thyroid dysfunction is common in the elderly and linked to liver abnormalities.
Nonalcoholic fatty liver disease (NAFLD) is a growing concern in aging populations.

Purpose of the Study:

To investigate the association between thyroid function and NAFLD in euthyroid elderly Chinese individuals.

Main Methods:

A cross-sectional study included 878 euthyroid elderly Chinese participants.
NAFLD diagnosis was based on established criteria.
Thyroid function, specifically serum-free thyroxine (FT4), was measured.

Main Results:

25.85% of participants had NAFLD.
NAFLD patients exhibited significantly lower serum FT4 levels compared to controls (P < 0.001).
NAFLD prevalence decreased with increasing serum FT4 levels (P for trend < 0.001).
Serum FT4 was negatively correlated with BMI, waist circumference, triglycerides, and uric acid.
Lower serum FT4 levels were significantly associated with an increased risk of NAFLD (OR: 0.847, P = 0.013).

Conclusions:

Thyroid function, even within the normal reference range, is associated with NAFLD in elderly Chinese.
Subtle variations in thyroid hormones may play a role in NAFLD development in this demographic.