Human rabies among the paediatric population in Bangladesh

A C Dey1, M Shahidullah, M A Hossain

  • 1Department of Neonatology, Bangabandhu Sheikh Mujib Medical University, Shahbagh, Dhaka, Bangladesh.

Insights

Children aged 5-10 years are most at risk for rabies, often from stray animal bites. Most unvaccinated children did not receive post-exposure prophylaxis, highlighting a critical gap in rabies prevention.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Rabies remains a significant public health concern, particularly in pediatric populations.
  • Understanding the epidemiological patterns of rabies in children is crucial for effective prevention and control strategies.

Purpose of the Study:

  • To investigate the clinical presentation, at-risk age groups, vaccination status, and incubation periods of rabies in children.
  • To identify key risk factors and patterns associated with rabies infection in a pediatric cohort.

Main Methods:

  • A cross-sectional study was conducted at the Infectious Disease Hospital (IDH), Dhaka, over one year (July 2008-June 2009).
  • Data was collected from case sheets of 70 children under 15 years with clinically diagnosed rabies.
  • Information included age, gender, geographical origin, bite details, vaccination status, animal type, and incubation period.

Main Results:

  • The most affected age group was 5-10 years (44.3%), with a male predominance (3:1).
  • Most cases (84.3%) were from rural areas, with bites predominantly on limbs (75.7%) and from stray dogs (97.1%).
  • A significant majority (84.3%) were unvaccinated, and the mean incubation period was 45.38 days (range: 11-150 days).

Conclusions:

  • Children aged 5-10 years are most vulnerable to rabies.
  • Bites from stray animals, particularly dogs, are the primary transmission route.
  • Inadequate post-exposure prophylaxis uptake is a major concern, necessitating improved public health interventions.

Related Concept Videos

Rabies01:28

Rabies

Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...
Rocky Mountain Spotted Fever01:26

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
Toxoplasmosis01:28

Toxoplasmosis

Toxoplasmosis, a zoonotic disease caused by the protozoan Toxoplasma gondii, poses significant public health challenges globally due to its high seroprevalence and varied clinical manifestations. As an obligate intracellular parasite, T. gondii can infect all warm-blooded vertebrates, but felids are its only definitive hosts, shedding unsporulated oocysts into the environment. Humans typically acquire the infection through ingestion of tissue cysts in undercooked meat or oocysts from...
Transmission of Pathogens01:24

Transmission of Pathogens

Pathogens spread from their reservoirs to susceptible hosts through three main routes: contact transmission, vehicle transmission, and vector transmission. Each route involves distinct mechanisms of transfer.Contact TransmissionThis category includes direct contact, indirect contact, and droplet transmission:Direct contact involves immediate physical interaction between individuals—such as a handshake—which can spread pathogens like Streptococcus pyogenes, the bacterium responsible for...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...