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Updated: Jun 2, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
[(1,2,5,6-η)-Cyclo-octa-1,5-diene]bis-(4-methyl-phen-yl)platinum(II)
Zhi-Wei Wang1, Ran Liu, Hong-Yu Liu
1Department of Chemistry, Capital Normal University, Beijing 100048, People's Republic of China.
Abstract:
In the mononuclear title complex, [Pt(C(7)H(7))(2)(C(8)H(12))], the Pt(II) ion exhibits a square-planar coordination geometry defined by two methyl-phenyl ligands and the mid-points of the two π-coordinated double bonds of cyclo-octa-1,5-diene. The two methyl-phenyl groups have a cis relationship with a C-Pt-C bond angle of 88.54 (18)° and a dihedral angle between the mean planes of the benzene rings of 83.87 (1)°. Each complex mol-ecule links to four symmetry-related ones through inter-molecular C-H⋯π inter-actions, forming a layer almost parallel to the bc plane.
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