Related Experiment Video
Updated: Jun 2, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
2-[4-(Carb-oxy-meth-yl)phen-oxy]acetic acid
1Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces, Institute of Physical Chemistry, Zhejiang Normal University, Jinhua, Zhejiang 321004, People's Republic of China.
Researchers synthesized a novel compound, C(10)H(10)O(5), using 4-hydroxy-phenyl-acetic acid and chloro-acetic acid. The resulting molecules form a unique three-dimensional crystal network through intermolecular hydrogen bonding.
Area of Science:
- Organic Chemistry
- Crystallography
Background:
- 4-hydroxy-phenyl-acetic acid is a common organic compound.
- Chloro-acetic acid is a reactive halogenated acetic acid derivative.
Purpose of the Study:
- To synthesize and characterize a novel compound, C(10)H(10)O(5).
- To investigate the crystal structure and intermolecular interactions of the synthesized compound.
Main Methods:
- Chemical synthesis involving the reaction of 4-hydroxy-phenyl-acetic acid with chloro-acetic acid.
- X-ray crystallography to determine the molecular and crystal structure.
Main Results:
- Successful synthesis of the title compound, C(10)H(10)O(5).
- Determination of a three-dimensional molecular network in the crystal structure.
- Identification of intermolecular O-H⋯O hydrogen bonding as the stabilizing force within the crystal network.
Conclusions:
- The reaction between 4-hydroxy-phenyl-acetic acid and chloro-acetic acid yields a novel compound with potential applications in materials science.
- The crystal structure reveals a robust 3D network stabilized by specific hydrogen bonding interactions, offering insights into molecular self-assembly.
Related Concept Videos
Carboxylic Acid Derivatives: Overview
Organic Compounds
IUPAC Nomenclature of Carboxylic Acids
For acyclic saturated monocarboxylic acids, the longest hydrocarbon chain containing the –COOH carbon is identified as the parent chain. Then, the last -e of the parent hydrocarbon name is replaced with a suffix -oic acid.
Nomenclature of Carboxylic Acid Derivatives: Acid Halides, Esters, and Acid Anhydrides
The IUPAC and common names of acid halides are derived from the corresponding carboxylic acids, by changing “ic acid” to “yl halide.” For example, as shown below, the IUPAC name ethanoyl chloride is derived from ethanoic acid, and the common name, acetyl chloride, is obtained from acetic acid.
Preparation of Carboxylic Acids: Overview
Loss of Carboxy Group as CO2: Decarboxylation of Malonic Acid Derivatives

