Related Experiment Video
Updated: Jun 2, 2026

Continuous Flow Chemistry: Reaction of Diphenyldiazomethane with p-Nitrobenzoic Acid
Published on: November 15, 2017
(E)-N'-(2,4-Dihy-droxy-benzyl-idene)-4-nitro-benzohydrazide
Nooraziah Mohd Lair1, Hamid Khaledi, Hapipah Mohd Ali
1Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Abstract:
The title compound, C(14)H(11)N(3)O(5), is essentially planar, with an r.m.s. deviation for the non-H atoms of 0.0832 (3) Å. In the crystal, O-H⋯O and N-H⋯O hydrogen bonds link adjacent mol-ecules into layers parallel to (101). These layers are further connected into a three-dimensional network via C-H⋯O inter-actions. In addition, a π-π inter-action occurs between the aromatic rings [centroid-centroid distance = 3.5425 (8) Å]. An intra-molecular O-H⋯N hydrogen bond is also observed.
More Related Videos
06:46Facile Preparation of (2Z,4E)-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
06:34Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)
Published on: June 20, 2014
Related Concept Videos
Diazonium Group Substitution: –OH and –H
Electrophilic Aromatic Substitution: Nitration of Benzene
1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Mechanism
Nitrosation of Enols
meta-Directing Deactivators: –NO2, –CN, –CHO, –⁠CO2R, –COR, –CO2H
1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Overview
The nitrous acid is unstable. Hence, it is formed in situ from a solution of sodium nitrite and cold aqueous acids such as hydrochloric or sulfuric acid. In an acidic solution, the –OH group of nitrous acid undergoes protonation to give oxonium ion, followed by water loss...