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Liquid Chromatography-Tandem Mass Spectrometry in Newborn Screening Laboratories

Michael H Gelb1, Khaja Basheeruddin2, Alberto Burlina3

  • 1Departments of Chemistry and Biochemistry, University of Washington, Seattle, WA 98195, USA.

International Journal of Neonatal Screening
|December 22, 2022
PubMed
Summary

Tandem mass spectrometry (MS/MS) is vital for newborn screening (NBS). Liquid chromatography-MS/MS (LC-MS/MS) offers advantages over flow-injection analysis-MS/MS (FIA-MS/MS) for multiplex screening, providing high throughput and cost-effectiveness.

Keywords:
dried blood spotsinborn errors of metabolismliquid chromatographynewborn screeningreflex testingtandem mass spectrometry

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