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Updated: Jun 2, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
[1-(Carb-oxy-meth-yl)cyclo-hex-yl]methanaminium nitrate
Elise J C de Vries1, Caryn Gamble, Ahmed Shaikjee
1Molecular Science Institute, School of Chemistry, University of the Witwatersrand, PO WITS, 2050 Johannesburg, South Africa.
Abstract:
The title compound, C(9)H(18)NO(2) (+)·NO(3) (-), is an anhydrous nitrate salt of gabapentin, which is formed serendipitously in the presence of selected non-coordinating metals. The crystal structure involves extensive hydrogen bonding between the -NH(3) (+) and -COOH groups and the nitrate anion.
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