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Related Experiment Video

Updated: Jun 2, 2026

Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion

Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion

Published on: March 18, 2014

Collagenous sprue.

Hugh James Freeman¹

¹Department of Medicine and Pathology, University of British Columbia, Vancouver, British Columbia. hughfree@shaw.ca

Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie

|April 28, 2011

Summary

This summary is machine-generated.

Collagenous sprue, a small bowel lesion causing malabsorption, presents with subepithelial collagen deposits. This condition, linked to celiac disease, may affect other GI sites and potentially serve as a paraneoplastic marker.

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Area of Science:

Gastroenterology
Gastrointestinal Pathology

Background:

Collagenous sprue is a rare small bowel mucosal lesion characterized by subepithelial collagen deposits.
It is historically associated with severe malabsorption, diarrhea, and weight loss, leading to multiple nutrient deficiencies.
Celiac disease shares similarities, including potential complications like ulceration, perforation, and lymphoma.

Purpose of the Study:

To review the characteristics and clinical significance of collagenous sprue.
To highlight the heterogeneity and potential extent of the mucosal process.
To discuss the diagnostic challenges and potential implications of collagen deposits.

Main Methods:

Review of existing literature on collagenous sprue.
Analysis of histopathological findings and clinical presentations.
Comparison with celiac disease and other gastrointestinal disorders.

Main Results:

Collagenous sprue involves distinct subepithelial collagen deposits in the small bowel mucosa.
The condition can extend to gastric and colonic sites, indicating significant heterogeneity.
Diagnosis in infancy suggests a potentially prolonged natural history.
Collagen deposits may represent a novel paraneoplastic histopathological marker.

Conclusions:

Collagenous sprue is a complex disorder with variable presentation and potential for widespread gastrointestinal involvement.
Further research into molecular and genetic biomarkers is crucial for defining subgroups and improving treatment strategies.
The condition's association with celiac disease and potential paraneoplastic role warrants further investigation.