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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...

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Updated: Jun 2, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Crohn's disease.

Sarah C Mills1, Alexander C von Roon, Paris P Tekkis

  • 1Lister Hospital, Stevenage, UK.

BMJ Clinical Evidence
|April 29, 2011
PubMed
Summary
This summary is machine-generated.

This systematic review evaluates medical, surgical, and lifestyle interventions for Crohn's disease remission. It synthesizes evidence on treatments like aminosalicylates, antibiotics, and surgery for effective Crohn's disease management.

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Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis

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Area of Science:

  • Gastroenterology
  • Immunology
  • Clinical Medicine

Background:

  • Crohn's disease is a chronic gastrointestinal inflammatory condition.
  • Characterized by transmural, granulomatous inflammation in a discontinuous pattern, often leading to fistulae.
  • Etiology is multifactorial, involving genetic predisposition, environmental factors, and mucosal immunity.

Purpose of the Study:

  • To systematically review the effectiveness of medical treatments for inducing remission in adult Crohn's disease.
  • To assess surgical interventions for inducing and maintaining remission in small-bowel and colonic Crohn's disease.
  • To evaluate medical and lifestyle interventions for maintaining remission in Crohn's disease, including post-surgery.

Main Methods:

  • Systematic review of medical literature up to December 2009, including Medline, Embase, and The Cochrane Library.
  • Inclusion of randomized controlled trials (RCTs), observational studies, and harms alerts from regulatory agencies (FDA, MHRA).
  • Focused on clinical questions regarding induction and maintenance of remission through various treatment modalities.

Main Results:

  • A total of 93 systematic reviews, RCTs, or observational studies met the inclusion criteria.
  • Evidence was gathered on a wide range of interventions for Crohn's disease.
  • The review identified studies relevant to the clinical questions posed.

Conclusions:

  • The review presents data on the effectiveness and safety of numerous interventions for Crohn's disease.
  • Interventions evaluated include aminosalicylates, antibiotics, immunomodulators (azathioprine/mercaptopurine, methotrexate, ciclosporin), biologics (infliximab), corticosteroids, nutritional therapies (enteral nutrition, fish oil), probiotics, and surgical options (resection, colectomy, strictureplasty).
  • Lifestyle interventions such as smoking cessation were also assessed for their role in maintaining remission.