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Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...

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Related Experiment Video

Updated: Jun 2, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

[Renal involvement in patients with systemic sclerosis].

Guillaume Bussone1, Laure-Hélène Noël, Luc Mouthon

  • 1Inserm, université Paris Descartes, institut Cochin, rue Méchain, Paris, France.

Nephrologie & Therapeutique
|April 29, 2011
PubMed
Summary

Scleroderma renal crisis, a complication of systemic sclerosis, involves severe hypertension and kidney failure. Early ACE inhibitor treatment improves outcomes, but prevention strategies remain unclear, advising caution with corticosteroids.

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Last Updated: Jun 2, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Area of Science:

  • Nephrology
  • Rheumatology
  • Internal Medicine

Context:

  • Scleroderma renal crisis (SRC) affects 2-5% of systemic sclerosis patients, particularly those with diffuse cutaneous disease.
  • High-dose corticosteroids (>15 mg/d) are linked to increased SRC risk.
  • Patients often present with heart failure and hypertensive encephalopathy.

Purpose:

  • To summarize the characteristics, diagnosis, treatment, and prognosis of scleroderma renal crisis.
  • To highlight the impact of angiotensin-converting enzyme (ACE) inhibitors on patient outcomes.
  • To discuss preventive measures and the role of renal biopsy.

Summary:

  • SRC presents with malignant hypertension and acute kidney injury, sometimes with thrombotic microangiopathy.
  • Diagnosis is primarily clinical; renal biopsy is reserved for atypical cases.
  • ACE inhibitors are crucial for managing hypertension and preserving renal function, though 5-year survival remains 65%.

Impact:

  • Early diagnosis and prompt treatment with ACE inhibitors significantly improve the prognosis of SRC.
  • Understanding risk factors like corticosteroid use is vital for prevention.
  • Further research is needed to establish consensus on SRC prevention strategies.