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Related Concept Videos

DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Principal component analysis-based filtering improves detection for Affymetrix gene expression arrays.

Jun Lu1, Robnet T Kerns, Shyamal D Peddada

  • 1Microarray and Genome Informatics Group, National Institute of Environmental Health Sciences, SRA International, Inc. and Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.

Nucleic Acids Research
|April 29, 2011
PubMed
Summary
This summary is machine-generated.

This study introduces a new filtering method for gene expression data using principal component analysis. The PVAC method improves the detection of significant gene expression changes while controlling false discoveries, outperforming existing techniques.

Failed At:

2026-06-19T13:36:36.976421+00:00

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