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Efficacy of CPP-ACP and CPP-ACPF on enamel remineralization - an in vitro study using scanning electron microscope
Jayanth Jayarajan1, P Janardhanam, P Jayakumar
1Department of Orthodontics, Meenakshi Ammal Dental College, Chennai, Tamil Nadu, India. jayan100@yahoo.com
Summary
Casein phosphopeptide-amorphous calcium phosphate fluoride (CPP-ACPF) and casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) effectively remineralize artificial enamel caries. CPP-ACPF demonstrated slightly superior remineralization compared to CPP-ACP.
Area of Science:
- Dental Science
- Biomaterials Science
Background:
- Remineralization is a key dental treatment for caries.
- Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and its fluoride-containing variant (CPP-ACPF) are investigated for enamel remineralization efficacy.
Purpose of the Study:
- To evaluate the in vitro efficacy of CPP-ACP and CPP-ACPF in remineralizing artificial caries lesions on human enamel.
- To compare the remineralization potential of CPP-ACP and CPP-ACPF using DIAGNOdent and scanning electron microscopy (SEM).
Main Methods:
- Ninety maxillary premolars were divided into three groups: artificial saliva, CPP-ACP, and CPP-ACPF.
- DIAGNOdent measurements were taken at baseline, after demineralization, and after remineralization.
- SEM analysis was performed on a subset of samples for surface evaluation.
Main Results:
- Both CPP-ACP (4.1 ± 1.8) and CPP-ACPF (4.8 ± 1.2) groups showed significantly higher remineralization than the control group (1.7 ± 0.7).
- CPP-ACPF exhibited marginally greater remineralization than CPP-ACP, likely due to the addition of fluoride.
Conclusions:
- All tested agents promoted statistically significant enamel remineralization.
- CPP-ACPF offers a slight advantage over CPP-ACP for remineralizing artificial enamel caries due to its fluoride content.
