[Platelet labelling with In-111-oxine: platelet survival and the images]

We studied 10 male and 2 female normal non-smoker volunteers (mean age 25) by labeling of autologous platelets with 111-In oxine. Daily samples for platelet survival were obtained in all, gamma-camera images in 10 and blood pool digital subtraction with 99m-Tc labeled erythrocytes in 6. Mean platelet count was 594 +/- 235 10(3)/mm3; collagen platelet aggregation pre and post labeling was 74 +/- 4.8 and 70 +/- 10%, respectively. Mean labeling efficacy was 65 +/- 15.4%, mean labeling dose was 201 +/- 79.5 microCi. A linearized initial survival of 7.9 +/- 1 day was obtained. Scintigraphic images showed circulating activity, greater in the spleen, persisting after digital subtraction. The method described can be used for clinical evaluation of platelet disorders and thrombosis.