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Related Concept Videos

Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...
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Candidiasis

Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...

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Related Experiment Video

Updated: Jun 2, 2026

Development of an In Vitro Ocular Platform to Test Contact Lenses
08:28

Development of an In Vitro Ocular Platform to Test Contact Lenses

Published on: April 6, 2016

A prototype antifungal contact lens.

Joseph B Ciolino1, Sarah P Hudson, Ashley N Mobbs

  • 1Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02115, USA.

Investigative Ophthalmology & Visual Science
|April 30, 2011
PubMed
Summary
This summary is machine-generated.

This study developed econazole-eluting contact lenses for treating fungal eye infections. These novel lenses demonstrated sustained antifungal activity against Candida albicans, offering a promising therapeutic option.

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Area of Science:

  • Ophthalmology
  • Materials Science
  • Mycology

Background:

  • Fungal ocular infections pose a significant threat to vision.
  • Current treatments may have limitations in efficacy and duration.
  • Novel drug delivery systems are needed for effective ocular antifungal therapy.

Purpose of the Study:

  • To design and develop a novel contact lens capable of delivering econazole.
  • To evaluate the antifungal efficacy and release kinetics of the econazole-eluting contact lens.
  • To investigate the potential of this contact lens as a treatment for fungal keratitis.

Main Methods:

  • Econazole-impregnated poly(lactic-co-glycolic) acid (PLGA) films were encapsulated within poly(hydroxyethyl methacrylate) (pHEMA) contact lenses via UV photopolymerization.
  • In vitro release studies were performed in phosphate-buffered saline at 37°C.
  • Antifungal assays were conducted against Candida albicans, and lens morphology was analyzed using scanning electron microscopy and Raman spectroscopy.

Main Results:

  • The developed contact lenses exhibited sustained econazole release.
  • The econazole-eluting contact lenses demonstrated extended antifungal activity against Candida albicans.
  • The duration and effectiveness of the fungicidal activity were dependent on the encapsulated econazole-PLGA film mass.

Conclusions:

  • Econazole-eluting contact lenses represent a viable strategy for treating fungal ocular infections.
  • This innovative drug delivery system shows potential for managing fungal keratitis.
  • Further in vivo studies are warranted to confirm clinical efficacy and safety.