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Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
10:49

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

Rotavirus surveillance --- worldwide, 2009

1

  • 1U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.

MMWR. Morbidity and Mortality Weekly Report
|April 30, 2011
PubMed

Insights

Rotavirus is a major cause of severe diarrhea in children globally. Surveillance data from 2009 shows a median of 36% of hospitalized children under five had rotavirus, highlighting the need for vaccination.

Area of Science:

  • Global Health
  • Infectious Diseases
  • Vaccinology

Background:

  • Rotavirus is the primary cause of severe diarrhea in children under five worldwide, responsible for significant mortality, especially in South Asia and sub-Saharan Africa.
  • The World Health Organization (WHO) recommended rotavirus vaccination in 2009 for all national immunization programs.
  • Disease burden data is crucial for decisions on rotavirus vaccine introduction and for monitoring vaccine impact.

Purpose of the Study:

  • To assess global rotavirus surveillance data from 2009.
  • To determine the proportion of rotavirus-associated hospitalizations in children under five.
  • To inform global vaccination strategies and surveillance efforts.

Main Methods:

  • Analysis of data from a WHO-coordinated global rotavirus surveillance network.
  • Inclusion of 43 countries that tested at least 100 stool specimens and reported for 12 months in 2009.
  • Standardized case definitions and laboratory methods at sentinel hospitals.

Main Results:

  • A median of 36% of hospitalized children under five with diarrhea tested positive for rotavirus across participating countries.
  • The positivity rate ranged from 25% to 47% across the six WHO regions.
  • Data confirmed the significant etiological role of rotavirus in childhood diarrhea hospitalizations.

Conclusions:

  • Rotavirus remains a major global cause of severe diarrhea hospitalizations in young children.
  • The findings underscore the importance of rotavirus vaccination for disease prevention.
  • Continued surveillance is essential for monitoring vaccine effectiveness and disease trends.

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