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Feasibility of a finger prick-based self-testing kit in first- and second-degree relatives of children with coeliac
Judith Pichler1, Matthias Zilbauer, Franco Torrente
1Department of Paediatrics and Adolescent Medicine, Medical University of Vienna, 1090 Vienna, Austria.
Insights
A finger prick test kit for coeliac disease (CD) relatives is feasible for home use. This reliable, easy-to-use Biocard™ test accurately identifies individuals needing further diagnosis.
Area of Science:
- Gastroenterology
- Clinical Diagnostics
- Genetics
Background:
- Coeliac disease (CD) is an autoimmune disorder triggered by gluten.
- First- and second-degree relatives of CD patients have a higher risk of developing the condition.
- Early detection and diagnosis of CD are crucial for managing the disease and preventing complications.
Purpose of the Study:
- To evaluate the feasibility of a finger prick-based self-testing kit for coeliac disease.
- To assess the usability and reliability of the Biocard™ test for relatives of CD patients.
- To determine the acceptance of home-based testing for coeliac disease screening.
Main Methods:
- A total of 379 first- and second-degree relatives of CD patients were invited to participate.
- Participants were provided with a Biocard™ self-testing kit and instructions for home use.
- Completed tests were returned for assessment by the study coordinator.
Main Results:
- 196 relatives completed the home test; 70% were children.
- The Biocard™ test was performed correctly in 97% of cases.
- Three positive tests were confirmed as coeliac disease via serology and histology.
Conclusions:
- The Biocard™ test is a reliable and user-friendly tool for coeliac disease home testing.
- The kit is well-accepted for self-testing by relatives of CD patients.
- Home-based screening can facilitate early identification of coeliac disease in at-risk individuals.
Aim:
To assess feasibility of a finger prick-based kit as method for self-testing of first and second-degree relatives of coeliac disease (CD) patients.
Methods:
A total number of 379 subjects were invited to participate in this study, consisting of 197 first-degree and 182 second-degree relatives of CD patients. The self-testing kit (Biocard™) was sent out with included instructions for use. Completed tests were sent back to the study coordinator for assessment.
Results:
One hundred and ninety-six invited relatives carried out the Biocard™ test at home. Amongst these, 70% were children. In 97% of the cases the test was performed correctly. Three tests revealed a positive result, all of which were later confirmed by serology and histology as coeliac disease.
Conclusion:
Our study indicates that Biocard™ test is a reliable, easy to use and well-accepted tool for home testing of first- and second-degree relatives of CD patients.
