Related Experiment Video

Updated: Jun 2, 2026

Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors
08:45

Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors

Published on: July 17, 2020

Protein tyrosine phosphatases

B Goldsmith1, S Koizumi

  • 1NOVARTIS PHARMA KK,NERVOUS SYST GRP,TAKARAZUKA RES INST,TAKARAZUKA,HYOGO 665,JAPAN.

International Journal of Oncology
|April 30, 2011
PubMed

Insights

Protein tyrosine phosphatases (PTPases) regulate cell signaling. Their dual role as tumor suppressors or promoters depends on cellular context, impacting cell proliferation and transformation.

Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Protein tyrosine phosphatases (PTPases) are crucial enzymes that counteract the activity of protein tyrosine kinases.
  • Aberrant tyrosine phosphorylation is linked to cellular proliferation and cancer development.
  • The precise role of PTPases in cancer, whether tumor suppressive or promoting, remains complex and context-dependent.

Purpose of the Study:

  • To explore the dual role of PTPases in cellular signaling and transformation.
  • To understand how PTPase activity influences tyrosine phosphorylation levels.
  • To investigate the implications of PTPase function in oncogenesis.

Main Methods:

  • Analysis of PTPase function in cellular models.
  • Assessment of tyrosine phosphorylation patterns.
  • Investigation of cellular proliferation and transformation assays.

Main Results:

  • PTPases can act as tumor suppressors by limiting oncogenic kinase activity.
  • Conversely, PTPases can promote proliferation by mediating mitogenic signaling pathways.
  • Inactive PTPase expression or overexpression of pro-proliferative PTPases can lead to cellular transformation.

Conclusions:

  • The function of PTPases is highly context-dependent.
  • PTPases can either inhibit or promote cancer progression based on their specific roles and cellular environment.
  • Understanding PTPase function is critical for developing targeted cancer therapies.

More Related Videos

Development and Application of Rapamycin-regulated Tyrosine Phosphatases06:56

Development and Application of Rapamycin-regulated Tyrosine Phosphatases

Published on: September 6, 2024

A Mass Spectrometry-Based Approach to Identify Phosphoprotein Phosphatases and their Interactors10:17

A Mass Spectrometry-Based Approach to Identify Phosphoprotein Phosphatases and their Interactors

Published on: April 29, 2022

Related Concept Videos

Protein Kinases and Phosphatases02:54

Protein Kinases and Phosphatases

Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
Protein Kinases and Phosphatases02:54

Protein Kinases and Phosphatases

Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Phosphorylation01:02

Phosphorylation

The addition or removal of phosphate groups from proteins is the most common chemical modification that regulates cellular processes. These modifications can affect the structure, activity, stability, and localization of proteins within cells as well as their interactions with other proteins.
During phosphorylation, protein kinases transfer the terminal phosphate group of ATP to specific amino acid side chains of substrate proteins. Serine, threonine, and tyrosine are the most commonly...
Phosphorylation01:02

Phosphorylation

The addition or removal of phosphate groups from proteins is the most common chemical modification that regulates cellular processes. These modifications can affect the structure, activity, stability, and localization of proteins within cells as well as their interactions with other proteins.
During phosphorylation, protein kinases transfer the terminal phosphate group of ATP to specific amino acid side chains of substrate proteins. Serine, threonine, and tyrosine are the most commonly...
Amplifying Signals via Enzymatic Cascade01:22

Amplifying Signals via Enzymatic Cascade

When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze the...