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Updated: Jun 2, 2026

An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus
Published on: August 25, 2017
Kaposi's sarcoma before and during the HIV epidemic in Tanzania
1MUHIMBILI UNIV,COLL HLTH SCI,DEPT PATHOL,DAR ES SALAAM,TANZANIA. MUHIMBILI UNIV,COLL HLTH SCI,DEPT SURG,DAR ES SALAAM,TANZANIA. MUHIMBILI UNIV,COLL HLTH SCI,DEPT EPIDEMIOL & BIOSTAT,DAR ES SALAAM,TANZANIA. KAROLINSKA HOSP & INST,IMMUNOPATHOL LAB,S-17176 STOCKHOLM,SWEDEN.
Abstract:
The Tanzania cancer registry recorded 39,920 cancer cases from 1968 to 1995. Kaposi's sarcoma (KS) constituted 4% of the cases of which 79.9% were males. During the AIDS period changes in the demographics of KS were noted showing an increase in the diagnosis of KS (p=0.0001). There was an overall decrease in the mean age from 41.7 years before to 37.3 years during the AIDS epidemic (p=0.002). In males this decreased from 42.7 to 38.8 years (p=0.01) but was not statistically significant in females (p=0.06). In both periods the cases were observed in the sexually active age groups. The narrowing of the male/female ratio during the AIDS period (p=0.0004), and an increase in extra-limb lesions from 19.7% before to 48.7% during the AIDS epidemic indicates the emergence of an aggressive form of KS in Tanzania, suggesting a co-factor role of HIV in KS pathogenesis.
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