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Malignant peritoneal mesothelioma presenting with persistent high fever

Li-ying Chen1, Ling-xiu Huang, Jin Wang

  • 1Department of Family Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Journal of Zhejiang University. Science. B
|April 30, 2011
PubMed

Insights

Malignant peritoneal mesothelioma (MPM) rarely spreads to the appendix. This case highlights MPM metastasis presenting as persistent fever, emphasizing its consideration in differential diagnoses for unexplained fevers.

Area of Science:

  • Oncology
  • Pathology

Background:

  • Malignant peritoneal mesothelioma (MPM) is a rare neoplasm originating in the peritoneum.
  • Diagnosis often relies on characteristic clinical and pathological findings.

Observation:

  • A 48-year-old female presented with persistent high fever and weight loss, initially unresponsive to antibiotics.
  • Computed tomography (CT) revealed omental thickening and nodules.

Findings:

  • Surgical exploration and subsequent histopathological examination confirmed appendiceal and bilateral adnexal metastases of MPM.
  • Microscopic and immunohistochemical analyses were crucial for diagnosis.

Implications:

  • This case underscores the importance of considering MPM in the differential diagnosis of unexplained persistent fever.
  • Awareness of atypical presentations, such as metastasis to the appendix, can aid in timely and accurate diagnosis of MPM.

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