Related Experiment Video
Updated: Jun 2, 2026

08:49
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Metastatic melanoma: an unusual presentation.
Ferdinando De Vita1, Guido Giordano, Alessio Fabozzi
1Division of Medical Oncology, F. Magrassi-A. Lanzara Department of Clinical and Experimental Medicine, Second University of Naples School of Medicine, II Policlinico, Naples.
Tumori
|May 3, 2011
Summary
This case report details a rare instance of malignant cutaneous melanoma spreading to the pleura and peritoneum five years post-surgery. It highlights the aggressive nature of this cancer and its potential for unusual metastatic patterns.
Area of Science:
- Oncology
- Pathology
Background:
- Malignant cutaneous melanoma is an aggressive skin cancer.
- Metastasis can occur widely throughout the body.
Observation:
- A case of malignant cutaneous melanoma metastasis to the pleura and peritoneum is described.
- This occurred 5 years after the primary lesion was surgically removed.
Findings:
- Pleural secondary lesions from melanoma are rare.
- The concurrent presence of peritoneal metastasis suggests an uncommon spread pattern.
Implications:
- This case expands understanding of melanoma's metastatic potential.
- It underscores the importance of monitoring for rare metastatic sites.
Related Concept Videos
Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Metastasis
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

