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Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas
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Rhabdomyosarcoma in children: a SEER population based study

Eduardo A Perez1, Noor Kassira, Michael C Cheung

  • 1Division of Pediatric Surgery and Division of Surgical Oncology, DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.

The Journal of Surgical Research
|May 3, 2011
PubMed

Insights

Pediatric rhabdomyosarcoma (RMS) incidence is 0.44/100,000 annually. Embryonal RMS, common in young children, shows better survival rates than other types, especially with early diagnosis and surgical resection.

Area of Science:

  • Pediatric Oncology
  • Cancer Epidemiology
  • Tumor Biology

Background:

  • Rhabdomyosarcoma (RMS) is a rare pediatric soft tissue sarcoma.
  • Understanding its incidence and outcomes is crucial for improving patient care.
  • Histological subtypes and patient demographics significantly influence prognosis.

Purpose of the Study:

  • To determine the incidence of pediatric rhabdomyosarcoma (RMS).
  • To analyze the outcomes and survival rates associated with pediatric RMS.
  • To identify prognostic factors influencing mortality in pediatric RMS patients.

Main Methods:

  • Utilized the Surveillance, Epidemiology, and End Results (SEER) registry.
  • Included patients diagnosed with RMS under 20 years of age.
  • Conducted univariate and multivariate analyses to identify predictors of mortality.

Main Results:

  • Identified 1544 pediatric RMS cases with an incidence of 0.44/100,000 annually.
  • Embryonal RMS (67%) was more common in younger children, while alveolar and pleomorphic types were more frequent in adolescents.
  • 5- and 10-year survival rates were 60% and 57%, respectively; factors like age < 10, localized disease, and embryonal type improved survival.

Conclusions:

  • Embryonal rhabdomyosarcoma (RMS) is the most common pediatric subtype, presenting in younger children with a better prognosis.
  • Favorable outcomes are associated with embryonal histology, favorable tumor location, age under 10, localized disease, and surgical resection.
  • Non-embryonal type, unfavorable sites, lack of surgery, older age, and distant disease independently predict higher mortality.
Abstract

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