Related Experiment Video
Updated: Jun 2, 2026

Stereotaxic Microinjection of Viral Vectors Expressing Cre Recombinase to Study the Role of Target Genes in Cocaine Conditioned Place Preference
Published on: July 30, 2013
Maybe a new killer in illicit cocaine.
1Institute of Legal Medicine, Catholic University of Sacred Heart, Rome, Italy. nadiafucci@rm.unicatt.it
A man died from a cocaine overdose, with toxicological analysis revealing a dangerous pesticide, 2,6-disopropylnaphthalene (2,6-DIPN), mixed with the drug. This finding highlights the potential for lethal contaminants in illicit substances.
Area of Science:
- Forensic Toxicology
- Analytical Chemistry
Background:
- Cocaine use is a significant public health concern.
- Illicit drug supply chains can introduce dangerous adulterants.
- Accurate detection methods are crucial for forensic investigations.
Observation:
- A deceased individual was found with evidence of cocaine use.
- Toxicological analysis confirmed acute cocaine intoxication as the cause of death.
- A pesticide, 2,6-disopropylnaphthalene (2,6-DIPN), was detected in nasal mucus and cocaine residue.
Findings:
- The presence of 2,6-DIPN, a hazardous fungicidal pesticide, was identified alongside cocaine.
- Gas chromatography/mass spectrometry (GC/MS) was used for precise toxicological analysis.
- A novel, simple, and selective GC/MS method was developed for 2,6-DIPN detection in cocaine.
Implications:
- This case underscores the risk of lethal pesticide adulteration in illicit cocaine.
- The developed GC/MS method can aid in identifying such dangerous contaminants.
- Forensic toxicology plays a vital role in understanding drug-related fatalities and public safety.
Related Concept Videos
Local Anesthetics: Chemistry and Structure-Activity Relationship
Adrenergic Agonists: Indirect-Acting Agents
One mechanism involves depleting stored catecholamines by displacing them from synaptic vesicles. These agents, known as "displacers," are transported into vesicles at the expense of noradrenaline. Examples include amphetamine and tyramine, which lack a catechol moiety, resulting in prolonged action, improved oral bioavailability, and...
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
Pharmaceutical Poisoning: Potential Scenarios
Stimulants
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
Drug Abuse and Addiction: Pharmacological Phenomena

