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Pleiotropy01:33

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
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Disorders of Erythrocytes

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Nondisjunction01:29

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During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.
Nondisjunction01:21

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Related Experiment Video

Updated: Jun 2, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

Idiopathic polydactylous longitudinal erythronychia.

Philip R Cohen1

  • 1The University of Houston Health Center, University of Houston, Houston, Texas; The Department of Dermatology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas; and The Department of Dermatology, University of Texas-Houston Medical School, Houston, Texas.

The Journal of Clinical and Aesthetic Dermatology
|May 3, 2011
PubMed
Summary
This summary is machine-generated.

Idiopathic polydactylous longitudinal erythronychia is a benign nail condition presenting as red bands on multiple nails. This common finding in men over 50 is usually asymptomatic and has no adverse effects.

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Last Updated: Jun 2, 2026

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05:39

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Published on: May 16, 2025

Area of Science:

  • Dermatology
  • Nail Diseases
  • Clinical Medicine

Background:

  • Longitudinal erythronychia (LE) is a linear red band on the nail plate.
  • Idiopathic polydactylous longitudinal erythronychia (IPLE) is a rare LE variant affecting multiple digits without underlying disease.

Observation:

  • IPLE was observed in 1% of adult dermatology patients, predominantly men over 50.
  • Affected nails (3-10 digits) showed narrow bands (<1mm) or wider bands (4-6mm).
  • Associated nail changes included hyperkeratosis, fissuring, leukonychia, red lunula, and splinter hemorrhages.

Findings:

  • IPLE is a benign, asymptomatic condition of unknown cause.
  • It presents as linear red bands on multiple digits, often unnoticed by patients.
  • No association with subungual tumors, dermatological, or systemic diseases was found.

Implications:

  • IPLE is a common, benign nail finding, possibly age-related.
  • It does not appear to have associated local or systemic adverse effects.
  • Understanding IPLE aids in accurate diagnosis and reassurance of patients presenting with nail changes.