Related Experiment Videos
Ventricular aneurysms complicating coxsackievirus group B, types 1 and 4 murine myocarditis
Abstract:
Suckling Swiss Webster mice were inoculated with 10(4)TCD50 of coxsackieviruses, group B types 1 or 4. Virulent necrotizing myocarditis resulted in 185 infected mice. Of the latter group, three (14.3%) nurslings on the 17th and 23rd day after inoculations had left ventricular aneurysms postmortem. None of 61 concurrently matched control mice developed aneurysms. Ventricular aneurysm is a suggested but previously undocumented complication of murine, and possibly human necrotizing transmural coxsackievirus myocarditis.
Insights
Coxsackievirus B infection in mice can cause severe myocarditis. A rare complication observed was left ventricular aneurysms, suggesting a potential link in human cases.
Area of Science:
- Cardiovascular Pathology
- Virology
- Pediatric Cardiology
Background:
- Coxsackievirus B infections are known to cause myocarditis.
- Necrotizing myocarditis can lead to significant cardiac damage.
Purpose of the Study:
- To investigate the potential for coxsackievirus B infection to cause ventricular aneurysms.
- To document a previously undocumented complication of coxsackievirus myocarditis.
Main Methods:
- Suckling Swiss Webster mice were inoculated with Coxsackievirus B types 1 or 4.
- Infected mice were monitored for cardiac complications, including aneurysms.
- Histopathological analysis was performed postmortem.
Main Results:
- 185 mice developed virulent necrotizing myocarditis.
- Three (14.3%) of the infected mice developed left ventricular aneurysms.
- No aneurysms were observed in control mice.
Conclusions:
- Left ventricular aneurysms are a potential complication of murine coxsackievirus B necrotizing myocarditis.
- This finding suggests a possible link to human cases of coxsackievirus-induced myocarditis.