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Quantifying the Waddington landscape and biological paths for development and differentiation

Jin Wang1, Kun Zhang, Li Xu

  • 1State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, People's Republic of China. jin.wang.1@stonybrook.edu

Proceedings of the National Academy of Sciences of the United States of America
|May 4, 2011
PubMed
Summary

We developed a theoretical framework to quantify the Waddington landscape and cell development paths. This model explains cell differentiation, stability, and reverse differentiation, revealing robust developmental dynamics.

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