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Updated: Jun 2, 2026
06:43
Robotic Duodenal Sleeve Resection for Gastrointestinal Stromal Tumor with Rare Exon 8 KIT Mutation Following Neoadjuvant Imatinib
Published on: April 3, 2026
[Gastrointestinal stromal tumor (GIST): case report]
Isabel Irene Rama Leal1, Herbeth Franco Queiroz, Thiago Santos Lima Almendra
1Hospital Universitário de Brasília, DF, BR.
Revista Do Colegio Brasileiro De Cirurgioes
|May 4, 2011
Summary
A high-grade Gastrointestinal Stromal Tumor (GIST) caused severe abdominal pain and acute abdomen in a middle-aged man. Surgical resection and subsequent treatment with Imatinib Mesylate offer therapeutic options for this aggressive cancer.
Area of Science:
- Gastroenterology
- Surgical Oncology
- Medical Oncology
Background:
- Gastrointestinal Stromal Tumors (GIST) are rare mesenchymal neoplasms.
- High-grade GISTs present diagnostic and therapeutic challenges due to their aggressive nature.
Observation:
- A male patient in his forties presented with progressive abdominal pain, weight loss, dyspnea, and lower limb edema.
- The patient developed a surgical acute abdomen, necessitating a segmental enterectomy for a 10 cm intestinal lesion.
Findings:
- Immunohistochemistry confirmed the resected lesion as a high-grade Gastrointestinal Stromal Tumor.
- The tumor exhibited high biological aggressiveness, indicating a poor prognosis without targeted therapy.
Implications:
- Early diagnosis and surgical intervention are crucial for managing GIST.
- Imatinib Mesylate (Gleevec) represents a significant therapeutic advancement for advanced or metastatic GIST.
- This case highlights the importance of multidisciplinary management for aggressive gastrointestinal stromal tumors.
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