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Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

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Normal PTH levels in primary hyperparathyroidism: still the same disease?

Amanda L Amin¹, Tracy S Wang, Thomas J Wade

¹Division of Surgical Oncology, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.

Annals of Surgical Oncology

|May 4, 2011

Summary

Primary hyperparathyroidism (pHPT) with normal parathyroid hormone (PTH) levels shows similar symptoms to elevated PTH. However, normal PTH pHPT patients have smaller adenomas and require more extensive surgery.

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Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

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Published on: March 14, 2017

Area of Science:

Endocrinology
Surgical Oncology

Background:

Primary hyperparathyroidism (pHPT) is a common endocrine disorder.
A subset of pHPT patients present with normal parathyroid hormone (PTH) levels, previously considered a milder form.

Purpose of the Study:

To investigate the clinical characteristics, laboratory values, imaging findings, and surgical outcomes of sporadic pHPT patients with normal PTH levels.
To compare these features against a matched cohort of pHPT patients with elevated PTH levels.

Main Methods:

A retrospective review of 861 sporadic pHPT patients who underwent parathyroidectomy.
Comparison of 58 patients with normal PTH (within 6 months pre-surgery) against 116 matched controls with elevated PTH.

Main Results:

No significant differences in preoperative calcium, symptoms, or bone health between normal and elevated PTH groups.
Normal PTH group had higher vitamin D, smaller adenomas, and more frequent bilateral neck exploration.
Preoperative imaging sensitivity trended lower in the normal PTH group.

Conclusions:

pHPT with normal or elevated PTH levels present similarly regarding symptoms and calcium.
Normal PTH pHPT is often associated with single-gland disease and smaller adenomas.
These factors may contribute to less sensitive imaging and increased need for four-gland exploration.