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Assessment of Pulmonary Capillary Blood Volume, Membrane Diffusing Capacity, and Intrapulmonary Arteriovenous Anastomoses During Exercise
Published on: February 20, 2017
Cardiopulmonary function and oxygen delivery during total liquid ventilation.
Charalambos Tsagogiorgas1, Markus Alb, Peter Herrmann
1Department of Anaesthesiology and Intensive Care Medicine, University Medical Center Mannheim, Mannheim, Germany. charalambos.tsagogiorgas@umm.de
Pediatric Pulmonology
|May 4, 2011
Summary
Total liquid ventilation (TLV) using perfluorocarbons did not significantly alter cardiopulmonary function or hemodynamics in normal rabbit lungs compared to conventional gas ventilation (CGV). This suggests TLV is safe for normal lungs.
Area of Science:
- Respiratory Physiology
- Critical Care Medicine
- Pulmonary Research
Background:
- Total liquid ventilation (TLV) with perfluorocarbons shows promise for injured/immature lungs.
- Hemodynamic effects of TLV in normal lungs are not well-established.
- Controversy exists regarding TLV's impact on healthy lung physiology.
Purpose of the Study:
- To compare cardiopulmonary and circulatory function changes between TLV and conventional gas ventilation (CGV).
- To determine the hemodynamic effects of TLV in non-injured adult rabbit lungs.
Main Methods:
- Prospective, controlled study involving 12 anesthetized adult New Zealand rabbits.
- Animals were randomized to either CGV or TLV groups after instrumentation for hemodynamic monitoring.
- TLV involved partial liquid ventilation with perfluoroctylbromide for 3 hours.
Main Results:
- No significant differences were observed in heart rate, cardiac output (CO), pulmonary artery pressure (PAP), mean arterial pressure (MAP), central venous pressure (CVP), or left atrial pressure (LAP) between TLV and CGV groups.
- Arterial and mixed venous blood gases, oxygen delivery, pulmonary vascular resistance (PVR), and systemic vascular resistance (SVR) also showed no significant variations.
Conclusions:
- Long-term TLV with suitable liquid tidal volumes does not significantly impair CO, blood pressure, or oxygen dynamics in non-injured rabbit lungs.
- These findings suggest TLV is hemodynamically safe for normal lungs when compared to CGV.
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