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Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System
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Exploring CCL18, eczema severity and atopy.

Kam Lun Hon1, Gary K Ching, Pak Cheung Ng

  • 1Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong. ehon@hotmail.com

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
|May 5, 2011
PubMed
Summary
This summary is machine-generated.

Childhood atopic dermatitis (AD) severity correlates with the chemokine CCL18/pulmonary and activation-regulated chemokine (PARC). Higher CCL18/PARC levels are linked to increased eosinophils and IgE, indicating its role in AD and atopy.

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Area of Science:

  • Immunology
  • Dermatology
  • Biochemistry

Background:

  • Childhood atopic dermatitis (AD) significantly impacts quality of life due to symptoms like pruritus and sleep disturbance.
  • The complex pathophysiology of AD may involve the chemokine CCL18, also known as pulmonary and activation-regulated chemokine (PARC).

Purpose of the Study:

  • To investigate the association between CCL18/PARC levels and key indicators of AD severity and patient experience.
  • Specifically, the study aimed to correlate CCL18/PARC with disease severity scores, quality of life, nocturnal scratching, eosinophil counts, and IgE levels.

Main Methods:

  • Recruited 108 pediatric patients diagnosed with AD, aged 20 years or younger.
  • Assessed disease severity using the SCORing Atopic Dermatitis (SCORAD) index and quality of life with the Children's Dermatology Life Quality Index (CDLQI).
  • Measured plasma CCL18/PARC concentrations, serum total IgE, and eosinophil counts, alongside nocturnal scratching activity via wrist motion monitors.

Main Results:

  • CCL18/PARC levels showed significant positive correlations with objective SCORAD scores, disease extent, and intensity.
  • Elevated CCL18/PARC was associated with increased pruritus and sleep loss, but not with CDLQI or nocturnal scratching.
  • Furthermore, CCL18/PARC levels correlated significantly with serum eosinophil counts and total IgE levels.

Conclusions:

  • Serum CCL18/PARC levels are demonstrably correlated with clinical severity in childhood atopic dermatitis.
  • The findings support a role for CCL18 in the pathogenesis of AD and atopy, alongside eosinophil and IgE involvement.