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Updated: Jun 2, 2026
07:14
Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds
Published on: July 11, 2025
Continuing intense malaria transmission in northern Uganda
Carla Proietti1, Davide D Pettinato, Bernard N Kanoi
1Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom. carla.proietti@lshtm.ac.uk
Summary
Malaria parasite prevalence remains high in politically unstable regions of Uganda, despite global reductions. Continued malaria control efforts are crucial in areas lacking large-scale interventions.
Area of Science:
- Medical Entomology
- Tropical Medicine
- Epidemiology
Background:
- Recent reports indicate reduced malaria transmission in parts of Africa, fostering optimism for elimination.
- However, the impact of political instability on malaria control trends remains unclear.
Purpose of the Study:
- To assess malaria parasite carriage and antibody responses in Apac, northern Uganda, a region affected by political unrest.
- To determine if malaria transmission trends observed elsewhere are present in areas with hindered control efforts.
Main Methods:
- Cross-sectional surveys were conducted in Apac, northern Uganda.
- Malaria parasite prevalence was determined using microscopy and polymerase chain reaction (PCR).
- Age-dependent antibody responses to Plasmodium falciparum antigens were analyzed.
Main Results:
- Under-five parasite prevalence was 55.8% (microscopy) and 71.9% (PCR).
- Plasmodium ovale and Plasmodium malariae were detected as co-infections.
- Age seroprevalence curves did not indicate recent changes in malaria transmission intensity.
Conclusions:
- Malaria control presents a significant challenge in areas lacking large-scale interventions, as exemplified by Apac district.
- Sustained efforts are necessary to combat malaria in regions affected by political instability and limited interventions.
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