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Related Experiment Video

Updated: Jun 2, 2026

The Ex vivo Preparation of Spinal Cord Slice for the Whole-Cell Patch-Clamp Recording in Motor Neurons During Spinal Cord Stimulation
06:55

The Ex vivo Preparation of Spinal Cord Slice for the Whole-Cell Patch-Clamp Recording in Motor Neurons During Spinal Cord Stimulation

Published on: September 8, 2023

Selective stimulation of the spinal cord surface using a stretchable microelectrode array.

Kathleen Williams Meacham1, Liang Guo, Stephen P Deweerth

  • 1The Laboratory for Neuroengineering, Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology Atlanta, GA, USA.

Frontiers in Neuroengineering
|May 5, 2011
PubMed
Summary
This summary is machine-generated.

New stretchable microelectrode arrays (sMEAs) offer effective, non-penetrating electrical stimulation of spinal cord tracts. These flexible arrays demonstrate comparable selectivity to rigid electrodes for activating neuronal populations.

Keywords:
PDMSbrain computer interfacemultielectrode arrayneurophysiologyneuroprosthesisneurorehabilitationspinal cordspinal cord injury

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Related Experiment Videos

Last Updated: Jun 2, 2026

The Ex vivo Preparation of Spinal Cord Slice for the Whole-Cell Patch-Clamp Recording in Motor Neurons During Spinal Cord Stimulation
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11:07

In Vivo Intracellular Recording of Type-Identified Rat Spinal Motoneurons During Trans-Spinal Direct Current Stimulation

Published on: May 11, 2020

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Spinal Cord Stimulation

Background:

  • Electrical stimulation of the spinal cord can modulate motor and sensory functions by activating neuronal populations.
  • Spinal tracts, or longitudinal columns of white-matter funiculi, provide access to these neurons via their axons.
  • Current methods often involve penetrating the spinal cord, posing risks and limitations.

Purpose of the Study:

  • To evaluate the efficacy of novel stretchable microelectrode arrays (sMEAs) for non-invasive electrical stimulation of spinal cord surface tracts.
  • To compare the selectivity and performance of sMEAs against traditional rigid microelectrodes in vitro.
  • To assess the potential of sMEAs for precise, site-specific activation of spinal axons.

Main Methods:

  • Fabrication of stretchable microelectrode arrays (sMEAs) using a polydimethylsiloxane substrate for circumferential spinal cord contact.
  • In vitro stimulation of rat spinal cords using sMEAs and rigid bipolar tungsten microelectrodes.
  • Measurement of evoked axonal compound action potentials (CAPs) to assess stimulus resolution and conduction velocities.
  • Dual-site stimulation experiments to evaluate spatial recruitment of spinal axons.

Main Results:

  • sMEAs demonstrated comparable stimulus resolution and evoked compound action potential (CAP) conduction velocity ranges to rigid microelectrodes.
  • Dual-site stimulation with sMEAs successfully recruited spatially distinct populations of spinal axons.
  • Site-specific stimulation of the ventrolateral funiculus using sMEAs evoked ventral root efferent activity across multiple spinal segments.

Conclusions:

  • Stretchable microelectrode arrays (sMEAs) provide selective spinal cord surface stimulation comparable to rigid electrodes.
  • sMEAs offer potential advantages in mechanical compatibility and circumferential contact with the spinal cord.
  • These findings support the development of sMEAs for advanced, non-penetrating spinal cord neuromodulation.