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Impact of hepatitis C in mortality in patients on hemodialysis

Cristian Paul Leon Rabanal1, Javier Cieza Zevallos, Roberto Cieza Cusato

  • 1Universidad Peruana Cayetano Heredia. cristianleonr27@hotmail.com

Jornal Brasileiro De Nefrologia
|May 5, 2011
PubMed

Insights

Hepatitis C infection did not increase mortality risk in patients undergoing hemodialysis. Survival rates were unexpectedly better for hepatitis C-infected patients compared to uninfected patients in this cohort study.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Epidemiology

Background:

  • Cardiovascular diseases are a primary cause of mortality in end-stage renal disease (ESRD) patients.
  • Viral infections, particularly hepatitis B and C, significantly impact survival and morbidity in hemodialysis patients.
  • Understanding the specific impact of hepatitis C on hemodialysis patient mortality is crucial.

Purpose of the Study:

  • To assess the influence of hepatitis C infection on the mortality rates of patients undergoing hemodialysis.
  • To investigate the relationship between hepatitis C and survival in ESRD patients on hemodialysis.

Main Methods:

  • A non-concurrent cohort study design was employed.
  • The study followed two cohorts of 74 patients each over a ten-year period.
  • Statistical analysis, including Cox-Mantel log-rank test, was used to compare survival rates.

Main Results:

  • Hepatitis C infection was not associated with an increased risk of death.
  • Patients infected with hepatitis C demonstrated better survival rates than uninfected patients.
  • One-year and five-year survival rates were 95.5% and 73.1% for hepatitis C-infected patients, versus 93.9% and 52.3% for non-infected patients (p = 0.02).

Conclusions:

  • Hepatitis C infection does not correlate with increased mortality in hemodialysis patients with ESRD.
  • The study found no increased mortality risk associated with hepatitis C in this patient population.
  • Survival outcomes were unexpectedly favorable in hepatitis C-infected hemodialysis patients.
Abstract

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