Related Experiment Video
Updated: Jun 2, 2026
06:29
Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay
Published on: March 1, 2011
The tale of TL1A in inflammation
1Department of Inflammation, Amgen Inc., Thousand Oaks, California, USA. hhsu@amgen.com
Mucosal Immunology
|May 6, 2011
Summary
Tumor necrosis factor ligand 1A (TL1A) is a protein produced by immune cells. Its receptor, DR3, is found on T cells, suggesting a role in immune cell communication.
Area of Science:
- Immunology
- Cell Biology
- Molecular Biology
Background:
- Tumor necrosis factor ligand 1A (TL1A), also known as TNFSF15, is a member of the TNF superfamily.
- TL1A is expressed by various immune and non-immune cells, including monocytes, macrophages, dendritic cells, synovial fibroblasts, and endothelial cells.
- Expression is induced by cytokines, immune complexes, and microbial stimuli.
Purpose of the Study:
- To describe the expression patterns and cellular interactions of TL1A and its receptor DR3.
- To highlight the potential role of the TL1A-DR3 axis in immune responses.
Main Methods:
- Review of existing literature on TL1A and DR3.
- Analysis of gene and protein expression data.
- Immune cell co-culture experiments (implied).
Main Results:
- TL1A is produced by a range of cell types upon stimulation.
- DR3, the cell surface receptor for TL1A, is primarily expressed on T cells.
- This differential expression suggests a specific ligand-receptor interaction between TL1A-expressing cells and T cells.
Conclusions:
- The TL1A-DR3 interaction is a key pathway in immune cell signaling.
- Understanding this pathway is crucial for developing immunomodulatory therapies.
Related Concept Videos
01:26Acute Inflammation I: Inflammatory Response
Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...
01:25Acute Inflammation III: Local and Systemic Effects
Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
01:38Inflammation
Overview
01:12Chronic Inflammation: Introduction
Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
01:30Inflammatory Response I: Vascular and Cellular
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
01:26Acute Inflammation II: Cellular Phase
The cellular phase of acute inflammation is a tightly orchestrated sequence of events that recruits leukocytes, primarily neutrophils, to sites of tissue injury or infection. Following the initial vascular changes, this phase ensures effective immune cell migration, activation, and function at the affected site to eliminate pathogens and initiate tissue repair.Leukocyte Recruitment CascadeLeukocyte recruitment happens in four steps: margination, adhesion, transmigration, and chemotaxis. Reduced...