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Related Experiment Video

Updated: Jun 2, 2026

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo
10:50

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

Published on: March 26, 2019

Vascular function and multiple sclerosis.

Anette S Fjeldstad1, John McDaniel, Melissa A H Witman

  • 1Division of Geriatrics, Department of Internal Medicine, George E. Whalen VA Medical Center, University of Utah, Salt Lake City, UT 84148, USA. a.fjeldstad@utah.edu

Journal of Neurology
|May 6, 2011
PubMed
Summary
This summary is machine-generated.

This study found no differences in vascular function, inflammation, or oxidative stress in multiple sclerosis (MS) patients compared to healthy controls. These factors are not necessarily elevated in MS patients in remission.

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Area of Science:

  • Neuroimmunology
  • Cardiovascular Science
  • Oxidative Stress Research

Background:

  • Multiple sclerosis (MS) is a neurological disease with potential links to cardiovascular issues.
  • Oxidative stress and vascular dysfunction are hypothesized contributors to MS pathology.
  • Understanding these links is crucial for managing MS comorbidities.

Purpose of the Study:

  • To investigate vascular function in MS patients.
  • To assess markers of oxidative stress and inflammation in MS.
  • To compare these parameters between MS patients and healthy controls.

Main Methods:

  • Evaluated brachial artery flow-mediated dilation (FMD) and reactive hyperemia in 14 MS patients and 13 controls.
  • Measured blood markers including C-reactive protein (CRP), lipid hydroperoxides (LH), FRAP, superoxide dismutase (SOD), and catalase.
  • Utilized ultrasound Doppler for vascular assessments.

Main Results:

  • No significant differences were observed in FMD or reactive hyperemia between MS patients and controls.
  • Inflammatory marker CRP and oxidative stress marker LH showed no significant group differences.
  • Vascular function, inflammation, and oxidative stress were not elevated in MS patients in remission.

Conclusions:

  • Impaired vascular function is not an obligatory feature of multiple sclerosis.
  • Elevated systemic inflammation and oxidative stress are not consistently present in MS patients, particularly those in remission.
  • These findings challenge the assumption of universal vascular compromise in MS.