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Updated: Jun 2, 2026

Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve
Published on: June 14, 2017
Therapeutic plasma proteins--application of proteomics in process optimization, validation, and analysis of the final
Dajana Gaso-Sokac1, Spomenka Kovac, James Clifton
1Department of Chemistry, J. J. Strossmayer Univeristy, Osijek, Croatia.
Abstract:
An overview is given on the application of proteomic technology in the monitoring of different steps during the production of therapeutic proteins from human plasma. Recent advances in this technology enable the use of proteomics as an advantageous tool for the validation of already existing processes, the development and fine tuning of new production steps, the characterization and quality control of final products, the detection of both harmful impurities and modifications of the therapeutic protein and the auditing of batch-to-batch variations. Further, use of proteomics for preclinical testing of new products, which can be either recombinant or plasma-derived, is also discussed.
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