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Updated: Jun 2, 2026

Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images

Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images

Published on: November 20, 2015

Cerebral microbleeds on MR imaging: comparison between 1.5 and 7T.

M M A Conijn¹, M I Geerlings, G-J Biessels

¹Department of Radiology, University Medical Center Utrecht, the Netherlands. m.conijn@umcutrecht.nl

AJNR. American Journal of Neuroradiology

|May 7, 2011

Summary

High-field 7T MRI imaging significantly improves the detection and reliability of cerebral microbleeds compared to standard 1.5T MRI. This advanced technique offers better visualization of these small vascular lesions.

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Area of Science:

Neuroimaging
Radiology
Vascular Neurology

Background:

Detection of cerebral microbleeds varies significantly across studies due to differing MRI protocols.
Standard 1.5T MRI protocols may limit the sensitivity for identifying microbleeds.

Purpose of the Study:

To compare the visualization and detection of cerebral microbleeds using 3D T2*-weighted imaging at 1.5 Tesla (T) versus 3D dual-echo T2*-weighted imaging at 7T.
To assess the reliability of microbleed detection at both magnetic field strengths.

Main Methods:

Thirty-four patients with atherosclerotic disease underwent both 1.5T 3D T2*-weighted and 7T 3D dual-echo T2*-weighted MRI.
Definite microbleeds were identified, and their presence and number were recorded.
Inter- and intraobserver reliability were evaluated using the Intraclass Correlation Coefficient (ICC).

Main Results:

7T MRI detected microbleeds in significantly more patients (50%) compared to 1.5T MRI (21%) (P = .001).
The number of microbleeds identified was also higher at 7T (median 0.5) than at 1.5T (median 0.0) (P = .002).
Interobserver reliability was higher at 7T (ICC = 0.61) than at 1.5T (ICC = 0.50), with excellent intraobserver reliability at both (0.94 for 7T, 0.59 for 1.5T).

Conclusions:

3D dual-echo T2*-weighted imaging at 7T provides superior detection of cerebral microbleeds compared to 1.5T imaging.
The 7T protocol demonstrates enhanced reliability for identifying microbleeds, crucial for understanding cerebrovascular disease.