Related Experiment Video
Updated: Jun 21, 2025
11:16
In vitro Assessment of Aortic Regurgitation Using Four-Dimensional Flow Magnetic Resonance Imaging
Published on: February 25, 2022
3.3K
Intra-Aneurysmal High-Resolution 4D MR Flow Imaging for Hemodynamic Imaging Markers in Intracranial Aneurysm
R J van Tuijl1,2, C S den Hertog3, K M Timmins1
1From the Department of Radiology (R.J.v.T., K.M.T., B.K.V., I.C.v.d.S.), University Medical Center Utrecht, Utrecht, the Netherlands.
AJNR. American Journal of Neuroradiology
|July 11, 2024
Summary
High-resolution 4D MR flow imaging reveals key hemodynamic markers, including wall shear stress (WSS) and oscillatory shear index (OSI), that correlate with unruptured intracranial aneurysm (IA) instability. These findings could improve prediction of aneurysm rupture risk.
Area of Science:
- Medical Imaging
- Biophysics
- Cardiovascular Research
Background:
- Predicting intracranial aneurysm (IA) instability is vital for guiding treatment and patient selection for preventive therapies.
- High-resolution 4D MR flow imaging and 3D morphological analysis offer potential new markers for IA instability.
Purpose of the Study:
- To identify 4D MR flow imaging markers for IA instability.
- To correlate hemodynamics within the aneurysm sac with 3D morphological parameters indicative of instability.
Main Methods:
- 35 patients with 37 unruptured IAs underwent 3T MRA and 7T 4D MRI flow scans.
- Five hemodynamic parameters (WSSMAX, WSSMEAN, OSI, mean velocity, velocity pulsatility index) were correlated with six 3D morphology parameters (major axis length, volume, surface area, flatness, shape index, curvedness).
Main Results:
- WSSMAX and WSSMEAN showed significant negative correlations with IA size parameters and positive correlations with shape index.
- OSI demonstrated strong positive correlations with major axis length and flatness, and negative correlations with shape index.
- Velocity pulsatility index did not yield statistically relevant correlations.
Conclusions:
- WSSMAX, WSSMEAN, and OSI are the most promising hemodynamic parameters correlating with IA instability.
- These novel imaging markers warrant further investigation in longitudinal studies for predicting IA instability.
