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Updated: Jun 2, 2026

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts
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Bone Marrow - Home of Versatile Stem Cells

Mariusz Z Ratajczak1, Ewa K Zuba-Surma, Wojtek Wojakowski

  • 1Stem Cell Institute, James Graham Brown Cancer Center, University of Louisville, USA.

Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur Transfusionsmedizin Und Immunhamatologie
|May 7, 2011
PubMed

SUMMARY: Bone marrow (BM) has been for many years primarily envisioned as the 'home organ' of hematopoietic stem cells (HSC). In this review we will discuss current views of the BM stem cell compartment and present data showing that BM in addition to HSC also contains a heterogeneous population of non-hematopoietic stem cells. These cells have been variously described in the literature as i) endothelial progenitor cells (EPC), ii) mes-enchymal stem cells (MSC), iii) multipotent adult progenitor cells (MAPC), iv) marrow-isolated adult multilineage inducible (MIAMI) cells, v) multipotent adult stem cells (MACS) and vi) very small embryonic-like (VSEL) stem cells. It is likely that in many cases similar or overlapping populations of primitive stem cells in the BM were detected using different experimental strategies and hence were assigned different names.

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