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Related Concept Videos

Integrins01:10

Integrins

Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...
Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
Activation of Integrins01:15

Activation of Integrins

Integrins bind ligands and transmit information from outside the cell to inside or vice-versa through an "outside-in signaling" or "inside-out signaling."
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding events provide an effective stimulus.

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Dual-modality Molecular Cartography: Integrating Multiplex mRNA Detection with Protein Imaging Mass Cytometry
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Dual-modality Molecular Cartography: Integrating Multiplex mRNA Detection with Protein Imaging Mass Cytometry

Published on: November 14, 2025

Multimodality Imaging of Integrin α(v)β(3) Expression.

Yin Zhang1, Yunan Yang, Weibo Cai

  • 11. Departments of Radiology and Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, USA.

Theranostics
|May 7, 2011
PubMed
Summary
This summary is machine-generated.

Multimodality molecular imaging combines techniques like PET, SPECT, MRI, and optical methods to study integrin α(v)β(3) expression. This synergistic approach offers advantages over single modalities, advancing diagnostic capabilities.

Keywords:
cancerintegrin αvβ3molecular imagingmultimodality imagingnanoparticle

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Area of Science:

  • Molecular Imaging
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Integrin α(v)β(3) is a key target in molecular imaging.
  • Single imaging modalities have limitations for comprehensive analysis.
  • Multimodality imaging offers synergistic advantages by combining detection methods.

Purpose of the Study:

  • To review multimodality imaging strategies for integrin α(v)β(3) expression.
  • To highlight the role of nanoparticle-based contrast agents.
  • To discuss future directions and clinical potential.

Main Methods:

  • Focus on dual- and multimodality imaging agents (PET/optical, SPECT/fluorescence, PET/MRI, SPECT/MRI, MRI/fluorescence).
  • Review of nanoparticle-based contrast agents for combined detection.
  • Analysis of studies demonstrating proof-of-principle for multimodality approaches.

Main Results:

  • Significant advancements in integrin α(v)β(3) imaging over the past decade.
  • Several PET/SPECT probes have undergone human studies.
  • Numerous proof-of-principle studies for dual- and multimodality imaging have been reported.

Conclusions:

  • Multimodality imaging, particularly with nanoparticle agents, enhances the study of integrin α(v)β(3).
  • Future agents combining PET/MRI/fluorescence show promise for clinical applications.
  • Continued growth in this field is expected to impact patient management.