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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Nectin4-targeted molecular imaging in solid tumors: Current status and future perspectives.

Yongshun Liu1,2, Wenpeng Huang1, Jingwei Zhou3

  • 1Department of Nuclear Medicine, Peking University First Hospital, Beijing, China.

View (Beijing, China)
|May 18, 2026
PubMed
Summary

Nectin cell adhesion molecule 4 (Nectin4) is upregulated in solid tumors, driving cancer progression. Nectin4-targeted molecular imaging offers vital diagnostic and therapeutic applications across various cancers.

Keywords:
Nectin cell adhesion molecule 4diagnosticmolecular imagingtheranostictumor

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Area of Science:

  • Oncology
  • Molecular Imaging
  • Biomarker Research

Background:

  • Nectin cell adhesion molecule 4 (Nectin4) is a Ca2+-independent adhesion molecule.
  • Nectin4 is minimally expressed in normal tissues but significantly upregulated in various solid tumors.
  • Nectin4 overexpression is linked to tumor proliferation, metastasis, angiogenesis, and poor prognosis.

Purpose of the Study:

  • To review advancements in Nectin4-targeted molecular imaging.
  • To explore theranostic applications of Nectin4 imaging in diverse cancers.
  • To evaluate current research, diagnostic performance, and limitations of Nectin4 imaging.

Main Methods:

  • Literature review of Nectin4-targeted molecular imaging research.
  • Focus on theranostic applications in breast, urothelial, gastric, pancreatic, ovarian, and colorectal cancers.
  • Evaluation of diagnostic performance and limitations of existing imaging techniques.

Main Results:

  • Nectin4-targeted molecular imaging, including PET, SPECT, and NIRF, enables visualization of Nectin4 expression.
  • Enfutumomab vedotin, targeting Nectin4, is approved for urothelial carcinoma, demonstrating therapeutic significance.
  • Nectin4 imaging is crucial for diagnosis, differentiation, treatment decisions, efficacy evaluation, and prognosis prediction.

Conclusions:

  • Nectin4-targeted molecular imaging holds significant potential for comprehensive cancer management.
  • Clinical implementation requires addressing current challenges to advance diagnostic and therapeutic strategies.
  • Further research is needed to optimize Nectin4 imaging for broad clinical application.