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Detection of SARS-CoV-2 Receptor-Binding Domain Antibody using a HiBiT-Based Bioreporter
Published on: August 12, 2021
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Promising methods for detection of novel coronavirus SARS-CoV-2
Ran Liu1, Aisi Fu1,2, Zixin Deng1,3,4
1Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of Education and Wuhan University School of Pharmaceutical Sciences Wuhan China.
View (Beijing, China)
|April 12, 2024
Summary
The novel coronavirus (COVID-19) outbreak necessitates rapid diagnostic tools. This report reviews six promising methods for detecting SARS-CoV-2, aiding early COVID-19 diagnosis and control.
Area of Science:
- Virology
- Molecular Biology
- Biotechnology
Background:
- The COVID-19 pandemic, originating in Wuhan, China, in December 2019, has caused widespread global health concerns.
- Nucleic acid amplification tests are currently critical for confirming COVID-19 infections.
Purpose of the Study:
- To summarize and evaluate six advanced diagnostic methods for SARS-CoV-2 detection.
- To discuss the principles, practicality, and potential for developing new early diagnostic techniques for COVID-19.
Main Methods:
- Whole-genome sequencing
- Real-time reverse transcription polymerase chain reaction (RT-PCR)
- Nanopore target sequencing
- Antibody-based immunoassay techniques
- Paper-based biomolecular sensors
- Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas system-based technology
Main Results:
- The report details the principles behind six promising SARS-CoV-2 detection technologies.
- It assesses the current scope and practical applicability of existing diagnostic products and methods.
- Potential avenues for developing novel early diagnostic tools are highlighted.
Conclusions:
- Several advanced molecular and biosensor technologies show promise for SARS-CoV-2 detection.
- Further development of these methods could significantly improve early diagnosis and management of COVID-19.
