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Integrin targeted delivery of gene therapeutics

Rudy L Juliano1, Xin Ming, Osamu Nakagawa

  • 1Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.

Theranostics
|May 7, 2011
PubMed
Summary

Integrins are targeted for delivering anti-cancer agents like antisense and siRNA oligonucleotides. Various methods link these therapeutic molecules to integrin-binding ligands, enhancing their delivery and efficacy.

Keywords:
Antisense and siRNA oligonucleotidesEndosome escape.Gene therapyIntegrinRGD peptides

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